2018?1'3???12???????1??·?a??a???????·??|?§??????????????o??o|è???o¤??????A?????????????????±?????·??|?§????????1??·?????¤§??°è???????????é?????????????????????§°a???1??????°è??a???????±?????oè?????a???1??·?????¤§??°è???????????é????????-?????·??|?§???????????-??????§????????±??o???éa???¤a???-??????-???????????1?°???¨??o?o?è'¨è°±????????????????-??????§???Bioequivalence???????§°a??BEa???????????é?????è??è???????????????????????è????????è§???3??1????-??¤???1é?????????1??????°è????????????±?BE???éa????????????§????????????
?1??·?????¤§??°è???????????é????????è???o?é??è?????é????????????1??·?????¤§??°è???????????é???????????????????'?3???????????1??·?????§??¤§?-|è???-|é??é??é?????????????????????????·??|??¨?????????è????????éa???¤è§???3??1????¤§??-?????o?????????é???o???????????????·??|???éa???¤è§???3??1?????-????????o?????????è??é????????????????·??|BE?????o??????????±???????è???????3?????o??-??a????????±?????o?????????éa???¤??-??????
??±?·|è?3??3????1??·?????¤§??°è???????????é????????è???o?é??è?????é???????????
?1??·?????§??¤§?-|è???-|é??é??é?????????????????????????·??|??¨?????????è????????éa???¤è§???3??1???
?¤§??-?????o?????????é???o???????????????·??|???éa???¤è§???3??1?????-????????o?????????è??é????????
??-????oo?????????é??????????????è?????????1??-???¨é???1'??1?????????????????????????????¨?-¤è???????????????????1è??????????????é???±???????????1?é???1??????????BEè??éa???¨è???????????è???¨???-?????????é?????é??è|?????????¨???é???????????????????·??|?§????????o???????????-?????1??????¨??·?'§????????????é??????????????????????a???????????¨??·?§??-|????±?BE???éa????2018?1'???????±???????è?????è?'??§è????·?·?????????3é???1??1'????????·??|?°???§??-????????·??±??o???????-??????§???éa???¤?????????????????????è????????????????3é????§é?¨?§???????è?????è?????è??è?????????o·????±????
???????????1?????±??o???è???13??°?°???o?o??????·??|???é???????2???è?2è°±-???é????2è???????????è'¨è°±è????¨??????????1??o???¨OpenLAB ECM?3????è??è????°????????¨???????????¨???????????????é????????é????????????1??????o?o???1????§???°?????????è??è??è?a?-??????1????????§?????????????¤§??°???é????¨??·??°?????????é????§???é?¤?o????è?°è????????è???¤?????????·??|??o?1??????°è?????????????¨é??è§???3??1???è??????????a??¨???è?????????????1è?-?????·???????¤?????????1?3????????????????????o???¨????????1è?-?-???1é???????????????????????
?1??·?????§??¤§?-|è???-|é??é??é?????????????????è?¨?¤o???a???????o??¨???è????°??????è???????????è????¨?oo????????????????????|???è?'?????¤?????????è???????????è???????|?-???????a??é????????a?????è??è?????????-??????§???éa?è?3??3é??è|?????????·??|????o§??????è§???3??1????°????????¤§????????????è§???3???éa???-é????°??????é???1???¨??¨BE???éa????é?o???????±????a??
?????·??|??¨?????????è????????éa???¤è§???3??1????¤§??-?????o?????????é???o?è?¨?¤o???a???????·??|??????è?'????o???o??¨??·?????3é??é??é??????????????????????????è??????-?????????????????o§??????è§???3??1????|?????1??????oBE???éa???¤??¨??·??????????°???????????·???·?????o????°???¨è??????-????é???????¨é?2?o??????????é??è????????????1??????°è?????????????????????°???±??????é????????????????????????-??????§???éa???¤?????±?????????è?????????????????è?????é??è?????????±????a??
?????·??|????1??·?????¤§??°è???????????é?????????????o??oè?????????°????è??BE???éa?é?o???????±?????-¤?¤????é????1???????????????è??BE/1?????'?o?è??éa?????????°????????????è?????????????1??????????1??°???????è???????1?¤???????é??è'¨é??????????????????????¨??¨????????°??o???è??è?????è????§????±?????1?????-¤??????????????°??o??'?????'?o?????????·??????????°'?13???