?????·??|?§??????????????o??o|è???o¤??????A???è???????????????????????PD-L1???22C3?????????è???????????????????????????-|?3???????PD-L1 IHC 22C3 pharmDx1??????????±???¨é???·2è?·??????é?????è??????????????????±????FDA?????1??????

è??????????1?3???°?·2è?·?????¨?o???????é?????é3???????è????????ESCC??????è??è????|?????? KEYTRUDA 2?????????????????????????2???????KEYTRUDA???????§?PD-1???????2????è??????????±é??????????????????????????????¤§?1??¤??????????/??°??o?§°??oé???2??????????é?????KEYTRUDA?·2è?·?????¨?o??2?????¤??????§?±?é?¨?????????è???§???§ESCC???è?????è???o????è????? FDA ??1??????????????1?3?è?¨?????????è????¤è?¨è?? PD-L1?????????é?3??§è????? a??10???????1??????¨??????????????¨èo??2???????é?'????1??????o??°??????è???±????

PD-L1 IHC 22C3 pharmDx????????????FDA??1????????¨?o???????ESCC???è??è????|?????? KEYTRUDA ?o??o??2?????????'é??è????-???ESCC???PD-L1 IHC 22C3 pharmDx??¨??????è?·???FDA??1????o???¨????????-?§????????±???????

?????·??|è????-?????o???????-|?o????é?¨???è??Sam Rahaè?¨?¤o???a??PD-L1???PD-1/PD-L1????????1????????????é??è|???????????????????é?????è?????è???¤???????è?????è???????????è???o??????????????2??????????????-|?????1???PD-L1??????????????????????°¤??oé??è|????é???????????PD-L1 IHC 22C3 pharmDx????????1?3????????±???¨é??è?·??1????????·??|è???¤???????è??????????????KEYTRUDA?2???????ESCC???è?????????????o???????-|?????????è????-???é?????é??è'¨é????????é????§??????????o|??????é??è????-?????????a??

2019?1'???é????????é??è???°?é????????????o|16000?oo?-??o?3???ESCC?o|???????????????é????????è????-?????????30%4???è???o????è??????o??1'????-??????o12%5???

?????·??|???é????????????????????????o?PD-L1 IHC 22C3 pharmDx???

KEYTRUDA ???????§??oo?o??????????é??????????????é??è???????o?oo????????????????????°?????1???è????¤???è?????KEYTRUDA???é????-PD-1??????é?????PD-L1???PD-L2?1?é?'???????o??????¨??????è??????'????????????±???è????¤???è?????????o·???è?????T?·??·'???è?????KEYTRUDA?????????é???????????????3???????????2??????1?3????é???????§?a???'???????2??????·?????¨è?????è???¤???????????±??????-?????°?o?éa?è?????

?????·??|??¨??????è??????????????????????o?o?????????????????-|??????????2????è????-?o§???é???????a?§°??¨???é?????è??????????·??|???é??????????????????????±??????????o?PD-L1 IHC 22C3 pharmDx???PD-L1 IHC 22C3 pharmDxè???????????????????????é???°????è??è?o??????NSCLC?????????é????????è??è?o??????GEJè?o???????°?è·?????????????????¤'é??é?¨é3???????è????????HNSCC??????è??è????|??????KEYTRUDA?2????????????¨è????¤??????è????????TPS?????????è????°NSCLC????????-???PD-L1è?¨è??????????¨??????é?3??§è????????CPS?????????è????°HNSCC????°?è·????????????????é????????è??è?o??????GEJè?o?????????ESCC????????-???PD-L1è?¨è?????

1 PD-L1 IHC 22C3 pharmDx [???è??è?'????1|]???Carpinteria, CA: Dako????????·??|???????-|è§???3??1??????2019???

2 Keytruda [???è??è?'????1|]???Kenilworth, NJ: Merck, Inc.; 2019???

3 American Cancer Society.Facts & Figures 2019. //www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and- figures/2019/cancer-facts-and-figures-2019.pdf???2019 ?1' 7 ??? 26 ???è??é????????

4 SEER Cancer Statistics Review 1975a?? 2016.National Cancer Institute. //seer.cancer.gov/csr/1975_2016/???2019 ?1' 7 ??? 26 ???è??é????????

5 Kahn, A.; Crowell, M.D.; Fleischer, D.E.Reducing the Risk of Esophageal Squamous Cell Carcinoma: Out with the Old; in with the New.Gastrointestinal Endoscopy. 2019, 89(4), 733a??735.