?????·??|?§??????????????o??o|è???o¤??????A?????????????????? Ki-67 ??????è???????????????????????????-|?3???????Ki-67 IHC MIB-1 pharmDx???Dako Omnis?????°?·2è?·??? FDA ???Food and Drug Administration?????????é?????è??????????????????±??????1????????¨?o???????è???????????é???¤????é??é?????????13è?o??????EBC?????????è??è?? ?????é??è'?è????????è????????????3?????3?è??è??è??????2??????????è?????é??è'?è????????é|???aè?·??1??¨?o??-¤?±??oo??¤???é??è|??????¨IHC????????1?3??????? Ki-67 è?¨è????????CDK 4/6????????????Ki-67??????è??????????±?????·??|????????????????????????
?o?è§?EBC????¤????é??é????1?o????????????????????????§è?3??3é??è|?????|????è???¤?è?????é??é??é?????è??????°±??????è?·?????3?o????è?????è?|??????????????'???????o????????2??????3?-???????è?????è???????????è??????2?????????????è????°EBC?¤????é??é????????è§???1?3????è|???o?o?è????¤??????????1???1????????????????????'?o????????????1???è??è????????è?????è???o?????????1??????è??????3???¨é???????? EBC ???è??????¤????é??é????? ??±?o? Ki-67???è?????????????3????????????The American Joint Committee on Cancer???????????????è??????§??????????AJC????·2?°????????????oè????-EBC???III?o§è????????????-¤???Ki-67?????????é??é??è????°???é??è|???????é?¨??????è????????è?????????o???¨????????· ??? ?????·??|é???o§??????è?????è????-?????o???????-|?o????é?¨???è??Sam Rahaè?¨?¤o???a????¨?o?Dako Omnisé????????è?2?13??°????????·??| Ki-67 ??????è???????????????????????????-|?3????Dako Omnis?????'é??è????-????????1?3????è???2????è??è??????????????è??????????????è????°???????13è?o??????EBC???????¤????é??é??????-¤???è????????è????????è?·???FDA??1????????oEBC ????¤????é??é??è????°??o????o???'?o??????3????????????????o?è???????'?¤????è?????Verzenio?2??????-è?·??????é??é??é?????è?????a?? ?-¤???è?·??1?|????????????·??|è???????¨????±?????????????????????¨?o???'?o??2?????o???¨??1é???????????????????????????1?è??????-??·???o?o????????????oé??è'¨é??????????·??§è????-????????1?3?????o?????????°???