?????·??|?§??????????????o??o|è???o¤??????A???è?????????????? PD-L1 ??????è???????????????????????????-|?3????PD-L1 IHC 28-8 pharmDx ?·2è?·?????§??? CE-IVD è?¤è????????????±???¨?o?è???±??????|??§?°?è·?????????? ???MIUC????????????è?????è????¤???è?? PD-L1 è?¨è?? a?? 1%??????è??è???????¨????????????è'????????????? PD-1 é????????????2????è???????§????2?OPDIVO??????o3?-|????°¤?????????nivolumab???è??è??è??????2??????? MIUC ???è?????
?°?è·???????????????¨?????? 10 ?¤§???è§??????????2020 ?1'??°?????????è??è??50??????????-??o??oo??°?o|??o21.2??? ?oo ???MIUC ???è?????è???§??¤????????o|??o 50% ???
PD-L1 ???????o???§????2?OPDIVO ?-???? PD-1 ????3??????????????????????PD-L1 ??????è???????????????????????????-|?3???????????±??o???¨??????????????§?????????????????????è??è??é????¨??§????2?è??è??è??????2??????? MIUC ???è?????
??? PD-L1 ??????è???????????????????????????-|?3?????????o??'é??è????-???è???????§????2???±????????¨????????§????2????????o?é|????????1??????????????????? PD-1 ??o??????????2??????1?3????????????????é????????????¤????é??é???????o MIUC ???è????|?????°????????????
?????·??|é???o§??????è?????è????-?????o???????-|é????????è?? Sam Raha è?¨?¤o???a???????·??|??o???????-|????????????è'¨?o§???????????? PD-L1 ?????????????????§??????é????§????????????é????'??°?????°???è??è??????????°??¨????????¨?o? MIUC ???è???????§????2?è??????2???????a??
PD-L1 ??????è???????????????????????????-|?3??????¨??§???è?·????????°é???o???? CE è?¤è?????????¤§?o??°?è·?????????????è????°???????2????é?????????????????è?????è????¤???è?? PD-L1 è?¨è?? a?? 1%??????????????1?2???§???é?¤???????¤????é??é??è??é????????è??è??è??è????§????2?è??????2??????? MIUC ???è????? ?-¤?????°é???o????è?·??1?|????????????·??|è???????¨????±?????????????????????¨?o???'?o??2?????o???¨??1é???????????????????????????1?è??????-??·???o?o????????????oé??è'¨é??????????·??§è????-????????1?3?????o?????????°??????
1 ???è???????????
2 John Michael DiBianco, Arvin K George, Daniel Su, Piyush K Agarwal.
Managing noninvasive recurrences after definitive treatment for muscle-invasive bladder cancer or high-grade upper tract urothelial carcinoma.
Curr Opin Urol. 2015 Sep;25(5):468-75