?????·??|?§???????é????????????o??o|è???o¤??????A???è????????????????????é?????è??????????????????±? (FDA) ?·2??1????????·??| Resolution ctDx FIRST ?????o??'é??è????- (CDx) ??¨?o?????????o??|KRAS G12C ??o????a?????????????é???°????è??è?o??? (NSCLC) ???è?????è???o????è?????è????? TM (adagrasib) ????2??????-?????????

?????o?????1??????KRAZATI??¨??????NSCLCé???o????????????'é??è????-è????????ctDx FIRST???FDA??1??????é|???a??2????'????NGS???????????±?????·??|??? ????????????è?????????-¤?¤????ctDx FIRST è??è?? FDA ??1?????¨?o?è?¨??????é??????-??????? (EGFR) ??o??????è????¤??????????????????è??è'¨??????????oo?????1??? NSCLC è????¤???è??????????????????????¨???

?????o???é?1????????????*???ctDX FIRST ??????????????????????o?109 ??a??o???????1??3???o????????????????????-????????????è?·é???????? (SNV)??????????????o?¤± (indel)?????·è'???°?????? (CNA) ???è????????

è?o??????????????·??§?????3??§??-??????è§???????????1????????1???????????-??o???????è|??????????????????????????????3?-??o???? 25%???1??±?o???a????????o????????????????¤§?¤???° NSCLC ???è????¨??????????????????è?????2?¤§?o| 14% ??? NSCLC ???è????o??| KRAS G12C ?a????????¤§?o| 32% ??? NSCLC ???è????? EGFR ??o?????????????o??a???????????-¤???è??é?1??°???????????oè???±????è?????????2??????3?-????????§??????·????????????è§???3??1??????3,4ctDx FIRST ??o NSCLC ???è????????è????¤?-|??????????o?????§???°?????????è????2????????????????o????????2?????2??????1??????

ctDx FIRST ???????????¨??°????????????????????????è???????-??a???è????¤ DNA (ctDNA) ?????o????????1?????????????????§??'??o??????????'???????????????????è???§?????????1?3???? 90% ?????????è?????é|?é?????5?-¤?¤??????2????'???????????o???o?o????????????1?3????????o??±?é????§????????????????????'??????????????¨è?????é?'??????è?????è?????é???2??????3?-????6

Mirati è?????????-|?????'é??è????-??????è?? Kenna Anderes è?¨?¤o???a????????è?·???????????????é???????o?????????????????o???????????o???é?????????oo??????é??è|?è??????????3é??????-?????????????è°??????o???????????·??|è????·è?'????o???o?????????è?????é????'?¤?a??????????3?-?a????o?????????????????????a??

Mirati é|???-????-|??? Alan Sandler ????-|??????è?¨?¤o???a???????????é????'????????·??|??????????????·??|è???¤????é????'?¤?é???????????????????????????????1?3?????????????è????¤???é??è|????????????o??'?o????????????????????????¨ Mirati?????????????3¨?o???o?????????è?????????'???|??????????1??????±??????è???|? ctDx FIRST è????·???????????1?o??????°????????????è?oè?3??3é??è|????a??

?????·??|è????-?????o???????-|?o????é?¨???è?? Sam Raha è?'é?????a???°? ctDx FIRST ?????????????????????????°±è????o??'?o????????????????????????o?????? NSCLC ???è?????????'???|????§??????±???????????·??|é??è§???? Mirati ???????????????è???????????????????o????????±???????????'?o??????3?????o?o? NGS ???è????-??1?3?????????o??1é????????????2????????????????a??

?|?é???o?è§???3?o??????????è??è'-?????'?¤??????????è?·è??é?? //www.aozhou2n.com/genomics/ctDxFIRST???

References:
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