Agilent Early Career Professor Award
Previous Agilent Early Career Professor Award Winners

2016 Focus: Contribution to the development of advanced Big Data technologies aimed at making breakthroughs in life science research and imaging for clinical diagnostics.

Verhaak ???????o? 2000 ?1'è?·???è?·??°???????o¨?¤§?-|?????????????-|?§??-|???????-|??????2006 ?1'è?·???è?·??°é1???1??1??????????§?????¤§?-|????-|??-???????-|???????-|??????é?????????????¨??????é??è?¨è??????·??????????éo????????·??-|é????????????¤§?-|è???o3?3????????????-???/????????·?????????????-|è????¤????§?????o???????????·??????? Dr. Verhaaka??s work on cancer genomics and computational biology and its impact on the molecular characterization of cancer are well known. During his graduate work he demonstrated that gene expression subtyping correlate with genomic alterations of Acute Myeloid Leukemia and provides prognostic value. As part of his postdoctoral research he further demonstrated that clinically distinct subtypes of Glioblastoma can be differentiated based on transcriptional profiling of the tumors. Dr. Verhaak joined MDACC in 2010 and has built an outstanding research program to analyze terabyte-sized data sets from DNA, RNA, epigenome and other sequencing approaches with the goal of investigating therapy resistance in glioma. In 2015 he published the genomic characteristics of longitudinally sampled glioblastoma tumors and is currently expanding this effort through development of the GLASS consortium.?? Dr. Verhaaka??s has also been a key player at TCGA and his computational pipelines for massively parallel processing of sequencing and microarray expression data are still being used. Dr. Verhaak joined JAX in October 2016.

His outstanding work has been recognized by a number of awards related to the genomics of glioblastoma, including the Wilson S. Stone Memorial Award in 2011, the Pediatric Brain Tumor Foundation Peter Steck Award in 2013, the Adult Basic Research Award from The Society for Neuro-Oncology in 2014 and the AAAS Martin and Rose Wachtel Cancer Research Award in 2016. (Press release)

2015 ?1'??|??1?oo????????¨??¨?o???o?????????????????§?????????????o???¨??-??? CRISPR/Cas ????????? RNA ??????????·±??????è§?????????¨??1é???????o??°??oè'???????

Guttman ????????¨ 2012 ?1'è??éo????????·??-|é?????????3?????o??o????????-|???????1????????????o?????·???????????????????????????è??????o?è?a?·±??????éa???¤???é???????¨ 2013 ?1' 6 ??????????o????????|??°??o?????·??-|é?????Guttman ????????¨ 2006 ?1'è?·????o???????????¤??3??°??o??¤§?-|???????-????????-|???è????????????-|????-|????-|????????????è????????????-|????????????????-|???????-|?????? Guttman ????????¨éo????????·??-|é???????????è??è?????????1??????¨?????·???????????????????·??????-?????°?1?è?¨????o?é??é????o???é?'é???????? RNA a?? lincRNA???lincRNA ??¨???è????-????????¨???????¤?????????????è??è??è?????è?????????????§è°?è????° X ???è?2????¤±?'????è?±????????'??????Guttman ??????é??è??????????°????????????????-|??1?3??????? RNA ????o???°????????°?o? lincRNA??????è??é??è?????è?2è'¨????-????è?????è'¨??????????o??????¨??? DNA ????????'???è?????è???¨???-???????-|????????-?¤o?o? lincRNA ????????¨??o?????????????·????è??é??????o? lincRNA ????????¨?????¨?????3??¨??1????????o???????????1???lincRNA ???è??????¤????????????3é????????è?????

??o??'?????°???è§? lincRNA ?|??????§?????o???è?¨è???¨??o???????è??????????3??????Guttman ??????è?????????·????é????1?????¨????'? lincRNA é??è???????1??????è?????è'¨???è?????è'¨?¤?????????????è????????è?3???????????1???è°???§??o??????????????????é???o???????????????¨ lincRNA ?????1??§???Guttman ??????è??è???????o?????o?13??¨??????è???·??¨?????¨???????/?¨??o??????1?3????

Guttman ????????????????·????è?·????o?è???¤????é?1???è??èa?????????-?????? 2012 ?1'????????????????????????é??????????????????????????è??è???|?????????????????????o 2014 ?1'a????±???????????? 30 ??? 30 ?2???????????§??-|???a??????????°é???¨????

2014 ?1'??|??1?oo????????¨?????????è????¤??-????-???§è'¨?????¨????-|???é???o§??????è?????é????????????????1é???????o?·¨?¤§è'???????

Blainey ???????o? 2012 ?1'??????éo????????·??-|é?????????·??¨??3???????éo????????·??-|é????????????????·????????????????????????è???????¨??¨?°???°???????????§???????-|???????-??·???·??'?????¨?o????????§??-|?o???¨???Blainey ??????éa???¤é????1????????????è????????????-????é????1?3??????¨??¨?????°?¤??????°???????????-?¤o????¤?è?a?????????????·??¨??3????????'???¨???

??¨???????¤§?-|??????è?o????·??????-???Blainey ???????±??¤o?o?è?????è'¨????-??§???¨??? DNA ???????????-è???3?????1?é??è????¨????-|??1???????¤?è?????è'¨???è??é????-????-|??1??????è§???3?o???????è?????é??é????????è??????-?è????? DNA ??????è?????è'¨?§???¨?????1 DNA è?o??????è??è?a????1??????°?o???·????§???¨?'???§?????°????§???????????-?????????o??????????????????Blainey ???????????¨??°?-? PCR?????????è?????é????????????????§??¨??o?????????????????????????o???°??????????o?????????????????o|???

??¨éo????????·??-|é??????????·????????????Blainey ??????é????1??????????????§?????????è????o???????-|é??????????????????o???¨??????????????????é??????????·?????????????§??-|????????????????????o??·????????????????????¨??°?13??°???è???¤??¤§?¤§???é????3é???·????????¨????é??é?????Blainey ????????????è?'????o??????o???????????¨??????è??????o??????¨??°??1?????¨????????°????·????????¨????

Dr. Blainey received a Bachelor of Science degree in Chemistry and a Bachelor of Arts degree in Mathematics in 2001 from the University of Washington, both cum laude. He received his Ph.D. in Physical Chemistry in 2007 from Harvard University. From 2007 to 2012 he worked at Stanford University as a post-doc in Stephen Quake's laboratory. (press release)

2013 ?1'??|??1?oo????????¨??????è????-é??????????o?·¨?¤§è'?????????????????????o???????-|??-è?????è'¨??????/?????o???????????????è?°???????¤???????????·???·???

Yu ???????o? 2009 ?1'????????????è??????¤§?-|è????2/è????¤?-|é?¨é?¨????-|?3?????????o?o????????????????????????1??¨è??????¤§?-|?????????é?1?????¨??¨?????¨??o???????-|????????????????-|??1?3?é???????????è?oè????¤??????????????¨??o???????1?????????¨?o???????è?o??????è????-???é?????????2????é?????????????????è?°?????? ??????è?o????????1è???¤§???é?¨?????·??§?oo??¤é???????±?????????è????¤??????é??é??????-???¨????¤§?·?????????????????2???????é?????????????1?3?è???¤?è?¨??????????±?????????????è?o?????????Yu ????????????????????????è?oè????¤?±???????é??????-|???è?¨è§?é??????-|???????????¨??¨????????oé?????è????¤???é??é?????????????3????????1?3???? Yu ??????é????¨??¨??o???????????????é??è????¤???????-|????1?é????¨?·±?o|????o???-?¤o??¨??????è?o??????????¨?è???±??????????é???????- DNA ??2??o?????????????¨?????????1?-???¨??????é?'?????°???????????2??o?????o????????|è???¤?é????????????????a???????±?è????????

Dr. Yu received a Bachelor of Medicine degree in 1998 from Peking University. She received her M.S. in Statistics in 2003 and her Ph.D. in Biomedical Engineering in 2004 from the University of Michigan. From 2004 to 2007 she worked at the HHMI and Michigan Center for Translational Pathology under Dr. Arul M. Chinnaiyan, M.D., Ph.D. (press release)

2012 ?1'??|??1?oo????????¨?????????????-|??????é??????????o?·¨?¤§è'?????????????????????o?????¨????????±??? (NMR) ??????????·±??1???é?????è?????è'¨????-?????????????è?????è?¤è?????

Dr. Mittermaier joined the faculty of the Department of Chemistry at McGill University in 2005 as an Assistant Professor and was promoted to Associate Professor in 2011. The aim of his research program at McGill University is to gain a better understanding of the relationship between the structure of biomolecules, their energetics, dynamic behavior and function by designing new experimental strategies to probe protein conformational transitions based on Nuclear Magnetic Resonance (NMR). ???????3???????è???o??????°??????è°???§???è?????è'¨/é?????????o??????¨?????????Mittermaier ??????é??è???°? NMR ????-??????'???é????-?3? (ITC) ?????°????????????????????°?o???1?????-??????è?????è'¨/é?????????o??????¨???è?¨???????????????éa???¤é????¨?·??¤o????????-é??è????? NMR ??????????§??o§???è?????è'¨??????è????|??????????????? ????????§??????????3????????????aé??è|???1????????¨è??????3??????-????¤§????-?????¤§????-????????????-???????????1?????±??·???é?°???é????????????°???±???è???¤??????1????'???§???Mittermaier ???????????????é???°? NMR???ITC ???????o?è?2???è°±??????????????-?¤o?o??¤??§???????????-??????¨??°????????o??????

Mittermaier received a B.Sc. in Biophysics in 1996 at the University of Guelph. He received his Ph.D. in 2003 in Biochemistry at the University of Toronto under Prof. Lewis E. Kay. (press release)

2011 ?1'??|??1?oo??????????????????????-|??¨????????'??????????-|é????????è?¨???è?????é??????????????é?????????????¤?§??????¤?§???????????-|?????o???????-|???è?????è'¨????-|??????è°?????-|?-???????é??è????3è?????????3?????????????è§?è§?è?·????·±???è?¤è?????????????'?????°?o?è§??????????

Jewett ???????o? 2009 ?1'????????????è??????¤§?-|?·??¨??-|é???????¨?-¤???è??è????o?o?é????¨?o?????-|???????????????é?????é??è|??o???¨??????????3????????????¨???è?????????-|???????????¨?????|?|??¤§?-|??????è???¤????????-|????1???¨??1éo|???????¤§?-|???????3???????????-|?????¨è????¤??aé?????é?????????o?????????????????????¨è?????è??????¤§?-|???????????¨???????¤§?-|è??è??????????????????1???¨?????????????-|é??????????o?o??·¨?¤§è'??????? Jewett ??¨?????|?|??¤§?-|??? James Swartz ???éa???¤??-???????o?????§?é???o§é????????????????????è??è???¤?è?????è'¨???????13??°???è??????13??°??°?·2?????oé??é??é??è?????è'¨????o§?13??°?1???¨?o???a??§???è??????????????????o§????°????è???¤????è???3????????o???¨?????2?·2è??è?? 50 ?1'?????? Jewett è??????o???¨???????o?é???°'?13è?????è'¨???????????????????????-??????è°?????°§?????·é????????è???????????è??è???¤???¨?????1è???????-è????????????'???? Jewett ??¨??1éo|???????¤§?-|??? Jens Nielsen ???éa???¤??-?????o?o?é????????é|???a??°???é??????????-??'????o?è?3?°??????a???è???±?????????°????????·??????è°??????????????????????è?????è'¨????o??????¨?????????Jewett ??????????o??????°??o??????è§??¨???????è°??¨?????????¨?o?????o§??±?3?????°'?13??°???è?·?????????????????1???????????¨è?????????????????è°?é??é???1?é?'??o???è???3???? In George Churcha??s lab at the Harvard Medical School, Jewett constructed ribosomes in vitro as a milestone towards a novel ribosome evolution platform and the construction of synthetic life. In a demonstration elusive for four decades, he showed that Escherichia coli ribosomes could be reconstituted in a one-step incubation procedure under chemical conditions that mimic the cytoplasm. Jewett also discovered that ribosomal RNA synthesis could be combined with ribosome self-assembly to make functionally active ribosomes. This advance promises to accelerate the development of synthetic ribosomes capable of producing and evolving non-natural peptide drugs and hybrid materials.

Jewett received a B.S. in Chemical Engineering in 1999 at the University of California, Los Angeles. He received his M.S. in 2001 and his Ph.D. in 2005 Chemical Engineering at Stanford University. (press release)

2010 ?1'??|??1?oo??????????3???????????-|é????????è?¨???è?????é??????????????é?????????????¤?§??????¤?§???????????-|?????o???????-|???è?????è'¨????-|??????è°?????-|?-???????é??è????3è?????????3?????????????è§?è§?è?·????·±???è?¤è?????????????'?????°?o?è§??????????

Michelle Chang ?????????è|?????o?????-|???????-???????è?????????-|?????????????·??¨?é???????????????????1?°???¨????-|???é???-|???????o???o????????????????????????é???????1é???????°??????è??è????¨?o??????????è??è??????????????????o§?????¨???????-|???è'¨??? Chang ????????¨éo????????·??-|é?????è?o????·??????-?¤§è????°è????¨?o?????§???¨??°???????????1?3????é??é??????3????è?·é??è?????é??????????¨??o???????1???oè'¨?-?è?|???????-?é?§é??????o?????????|????o???¨??°è§?è§??????1????????? Joanne Stubbe ?°?è?????é???????¨??????è????·??oa??????????3???a???????????????·???????é?'?????1??¨????·??¤§?-|?????????????????? Jay Keasling ??±?o??????1???è|????????????¨???è°??·??¨?????o§??????è??????1???¨??-???é?'???è?·????o??????????Chang ????????????????±??o???3?o??????????è°??·??¨????????-|?????????????-|??1?3?????????¨??°?2??????§????-???????????????????????????? ?-¤é?1?·?????????????é???????????è???¨????è???¤?????????§??????????o???o????????????è??è????o?????a?????-???é??è????o????·??¨???1?3?è???????o?¤§è?????è?????é?????è???-?é???????????????????????é??????????1?????¨???????o???o???????-|???è?????è'¨????-|?????1?3?é?'????????¨?o??????o??????????-??????°???é???????¨????-|?2????é??????????1é????1???????°??°????????¤??????????????°?????-???-?????¨????????????é??????????1è?'????o?????????o????·??¨???1é??????????????è§??¤??????????é????-?????¨è'¨?'???????è???????????????-???'????o?è???????o??????????????????????????1è??????????o?o??????¨?¤§è?????è??????o§???é???????-?-?é????????????1?é???????????é???????'??·???????????????é??????????? Professor Michelle Chang is a rising star, helping to pioneer the field of synthetic biology. Her work has already borne fruit in the form of an anti-malarial drug that Sanofi-Aventis is pursuing. We can expect other great things from her in the future. Chang ???????o? 2004 - 2007 ?1'é?'??¨ Jay Keasling ?????????????-|?·??¨????éa???¤??-????o???????????·???????????????1???????o????????|??°??o??¤§?-|???????????????????-|?3??????1??????é??????????±??????è?¨?o?????????3?o??????¨??o????·??¨???1é?????è??????o§???????±?????????????????????????è?????é??è???'?????????????è??????'????é????????è?o??????

Professor Chang received a B.S. in biochemistry and a B.A. in French literature in 1997 at UC San Diego. In 2004, she earned her Ph.D. at MIT with Daniel Nocera and JoAnne Stubbe with whom she studied ribonucleotide reductase, an enzyme essential for DNA synthesis. ()

Boris Murmann ?????????????oo???é????°???è?????????¨???????è·?è??è???????1??????2003 ?1'???Murmann ????????¨?????????è?o???????????¨?????o??????è·? IEEE ?????????(IEEE J. Solid-State Circuits) ???è?¨??????è???1??3?é??è?????????????-?±??¤o?o????é????1é???o§??°?-??????·?¤????????????????è????¨è?????????o? 100 nm CMOS ?¨????è???¤???§è??é??????-?????3??????§è????????????????????????????????é????o?o?è???¤§?¤§????°? A/D è???????¨???é??è???o?????¤???a?????1??? A/D è???????¨??????????????????è????±????o?è???¤??oo??1?¨???????è·?è??è???§??-|???????3???? After earning his doctorate at the University of California at Berkeley, he joined the faculty of Electrical Engineering at Stanford University where he continues to work on radical approaches to the problems of data conversion and analog circuits in general. It is rare for a person to make such an important and transformative contribution to a well-established field. Dr. Murmann is one of the Principal Investigators of the Rethinking Analog Design initiative at Stanford. Beyond his core research, Professor Murmann is engaged in a number of interdisciplinary programs in areas such as biosensing, microresonators and organic electronics. He has been cited at Berkeley and at Stanford for excellence in teaching. Dr. Murmann has quickly become one of the leading thinkers and speakers on how to move analog design forward in an increasingly digital-centric world. His four most-read- and best-paper awards attest to his eloquence and influence in the industry at large.