6475 LC/TQ coupled with the 1290 Infinity II LC
6475 Triple Quadrupole LC/MS
The new Agilent 6475 triple quadrupole LC/MS is the latest evolution of the reliable LC/MS/MS workhorse customers trust the most. This sensitive, robust, and versatile triple quadrupole mass spectrometer employs several technological advantages like the superheated Agilent Jet Stream (AJS) ion source, curved and tapered collision cell, heated hyperbolic quadrupoles, and ± 20 kV high-energy dynode detector system. The 6475 LC/TQ also features instrument intelligence technologies such as early maintenance feedback, scheduled tune and check-tune, and intelligent secondary injection workflows.
Through advanced hardware, required limits of detection for the analysis of pesticides, veterinary drugs, PFAS, nitrosamines, and other regulated methods can easily be achieved day in and day out. Coupled with sophisticated, yet easy to use onboard instrument intelligence, your lab can maximize uptime, maintain peak instrument performance, help anticipate maintenance events, and achieve confidence in your results.
Through advanced hardware, required limits of detection for the analysis of pesticides, veterinary drugs, PFAS, nitrosamines, and other regulated methods can easily be achieved day in and day out. Coupled with sophisticated, yet easy to use onboard instrument intelligence, your lab can maximize uptime, maintain peak instrument performance, help anticipate maintenance events, and achieve confidence in your results.
- Triple Quadrupole LC/MS
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Product Details
Features
- Multiple versatile and easy-to-configure ion sources including AJS, ESI, APCI, and MMI allow you to tackle any type of LC/MS analysis
- Wide mass range allows the analysis of ions of various classes and sizes, from small molecules to multiply charged peptides
- VacShield allows you to do front-end ion injector maintenance without breaking vacuum, drastically reducing routine maintenance from at least 6 hours to 30 minutes
- Early maintenance feedback (EMF) provides instrument health and status reports by reporting actively monitored metrics so you can anticipate downtime or address an immediate issue
- Intelligent reflex ensures that results are within operational limits through active monitoring of sample carryover and samples above calibration range, adding additional blanks or reducing sample volume if one of these conditions is met
- Fast screening workflow with intelligent reflex dramatically improves sample throughput with a shortened LC method for screening and a standard method for quantitation; if a target is detected during screening, the sample is reinjected using a standard quantitation method.
- Built-in technical controls combined with procedural controls ensure the security of your data, control access, and facilitate compliance as defined by US FDA 21 CFR Part 11, EU Annex 11, and similar national electronic record regulation
Specifications
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| Instrument Health Tracking |
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Technology
Instrument intelligence for non-stop productivity with powerful LC/TQ systems
Agilent triple quadrupole LC/MS instruments (LC/TQ), designed to provide rugged and robust analysis, have now been augmented with enhanced instrument intelligence to maximize sample throughput, keep your analysis within tolerance, and prevent unexpected maintenance events. Obtain peace of mind with the Agilent 6475 LC/TQ with MassHunter 12 software for non-stop productivity. Learn MoreHow It Works
Applications
Literature
- Application Notes
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Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Samples Per EPA Draft Method 1633 Using the Agilent 6470 Triple Quadrupole Mass Spectrometer
PFAS analysis in aqueous aamples per EPA draft Method 1633 with the Agilent 6470 LC/TQ- Application Notes
- English
- 17 Jul 2024
- 865.86 KB
Intelligent Reflex Fast Screening for Drugs in Urine
This application note demonstrates the use of the intelligent reflex fast screening function within MassHunter acquisition software to improve batch completion time.- Application Notes
- English
- 17 Nov 2023
- 2.87 MB
Quantitation of over 1,000 Pesticide Residues in Tomato
A comprehensive multiresidue workflow was developed and validated for the simultaneous quantitation of over 1,000 pesticide residues in tomato to accelerate and simplify routine laboratory food testing.- Application Notes
- English
- 07 Nov 2023
- 772.52 KB
Agilent 6475 LC/TQ Performance Highlights with EPA Method 1633 for PFAS Analysis
This application note details the performance of the Agilent 6475 LC/TQ and 1290 Infinity II LC for PFAS analysis in accordance with the third draft of EPA 1633.- Application Notes
- English
- 25 Jul 2023
- 362.07 KB
Determination of Nitrosamine Impurities Using the Agilent 6475 LC/TQ
Evaluates the quantification performance of eight nitrosamine impurities using the Agilent 6475 triple quadrupole LC/MS (LC/TQ) system.- Application Notes
- English
- 30 Mar 2023
- 739.18 KB
Method Development and Evaluation for Multiresidue Pesticides in Food with 6475 LC/TQ
Development and evaluation of a comprehensive LC/MS/MS method for over 500 pesticide analyses in three food matrices (wheat, olive oil, and black tea).- Application Notes
- English
- 26 Sep 2022
- 1.27 MB
Highly Sensitive Quantification of Mutagenic Nitrosamine Drug Substance Related Impurity (NDSRI) N-Nitroso Propranolol in Propranolol API and 40 mg Tablets Using LC/MS/MS
In this application note, a method for the quantification of mutagenic Nitrosamine drug substance related impurity is described.- Application Notes
- English
- 16 Aug 2022
- 770.02 KB
Simultaneous Detection and Quantitation of 14 Fat-Soluble Vitamins and Carotenoids in Supplement by LC/MS/MS Triple-Quadrupole
In this application note, a method for the simultaneous identification and quantitation of fat-soluble vitamins and selected carotenoids in a complex supplement matrix is described.- Application Notes
- English
- 04 Aug 2022
- 1.20 MB
Analysis of Perfluorinated Compounds in Textile and Leather using the Agilent 6470 Triple Quadrupole LC/MS
The study describes a rapid, sensitive, and accurate LC/MS/MS method for the identification and quantification of 33 PFAS in fabrics.- Application Notes
- English
- 12 Apr 2022
- 527.15 KB
Highly Sensitive LC/MS/MS Method for the Simultaneous Quantification of Mutagenic Azido Impurity Analogues in Five Different Sartan APIs and Formulations
In this application note, two methods are described for the analysis of azido impurity analogues in five sartan API formulations.- Application Notes
- English
- 31 Jan 2022
- 1.41 MB
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MassHunter Networked Workstation Functional Design Specifications
This document contains the Functional Design Specifications for your Agilent MassHunter Networked Workstation system.- Specifications
- English
- 17 Nov 2022
- 13.06 MB
Agilent 6475 Triple Quad LC/MS System User Guide
This guide provides information on the 6475A LC/TQ system.- User Manuals
- English
- 25 May 2023
- 4.93 MB
MassHunter Workstation 12.0 LC/TQ Installation Guide
This book provides instructions to install the MassHunter Workstation software in these configurations: ? Workstation (standalone, no content management) ? Networked Workstation (networked, with content management on separate server)- Installation Guides
- English
- 17 Nov 2022
- 2.56 MB
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Tools
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Videos
Training & Events
Smart pesticide LC/MS mega methods!
Routine screening of 500 pesticides using an intelligent triple quadrupole LC/MS platform
Here we presented the process of developing a pesticide mega-method workflow on the new "6475 triple quadrupole LC/MS" to simultaneously detect and quantify over 500 pesticides of concern in various food matrices.
Webinar/Training
New Mass Spec Systems with Transformational Enhanced Intelligence
See how enhanced intelligence has transformed LC/MS and GC/MS capabilities.
Webinar/Training
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Develop skills and improve lab productivity with a wide variety of learning options from Agilent Education.
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Events
News
Sustainability is closely tied to our mission to advance the quality of life. It drives our efforts to be a leading sustainable lab partner to our customers, to work toward a clean-energy future, and to be a top employer of diverse and inclusive talent. We're honored to be ranked in the top 20 of Time magazine's 500 most sustainable companies in the world.
- 22 Jul 2024
6475 Triple Quadrupole receives ACT label from My Green Lab
Independently audited by SMS Collective, LLC (SMSC), and published by My Green Lab, the ACT label from My Green Lab provides information about the environmental impact of the product throughout its life cycle. My Green Lab is a nonprofit dedicated to improving the sustainability of scientific research.- 6475 Triple Quadrupole receives ACT label from My Green Lab
- 17 May 2022
The Scientists’ Choice Awards recognize the world’s most innovative and effective analytical technologies. Based on votes from scientists around the world, the Agilent 6475 triple quadrupole LC/MS system won the award for Best Spectroscopy Product of 2022!
- 06 Jun 2023
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