1290 Infinity II Bio Online LC System
The 1290 Infinity II Bio Online LC System is an online UHPLC system designed for comprehensive analysis and real-time bioprocess monitoring in the pharmaceutical industry. Combining the high-performance and biocompatible features of the 1290 Infinity II Bio LC System with the real-time monitoring capabilities of the 1260 Infinity II Prime Online LC System, this integrated system empowers scientists with enhanced capabilities and efficient control over their process analytical technology (PAT) needs.
This bioprocess Online monitoring UHPLC system enables precise separation and analysis of biomolecules, while providing real-time process monitoring, immediate feedback for optimization, and significant time and resource savings.
This bioprocess Online monitoring UHPLC system enables precise separation and analysis of biomolecules, while providing real-time process monitoring, immediate feedback for optimization, and significant time and resource savings.
Product Details
Features
- Offers dedicated process analytical technology (PAT) tool for online and at-line bioprocess analysis via LC applications
- Combines ultrahigh pressure up to 1300 bar and high analytical flow rates up to 5 mL/min for maximum online UHPLC performance
- Enables fast bioprocess monitoring of critical process parameters (CPPs) and critical quality attributes (CQAs) via direct injections, providing real-time data for greater control and faster understanding of processes
- Features a retain-sample functionality for dilutions (including reaction quenching), multimethod analysis, automated sample preparation, and additional offline quality control for sample archiving purposes
- Brings hybrid injection technology to the LC world: supports both classical flowthrough injection and Agilent Feed Injection for seamless method transfer and mediation of strong sample diluent effects
- Allows for intuitive sample scheduling via Online LC Monitoring Software, with quick setup of sampling events and clear data visualization through tools such as trending plots
- Easy real-time process monitoring; compatible with OpenLab CDS 2 and designed for process applications
- Ensures integrity of biomolecules and minimizes unwanted surface interactions through biocompatible solvent and sample flow path
- Offers enhanced flexibility through high salt tolerance and wide pH range, providing robustness for increased instrument uptime
- Includes wide range of sensitive optical detection capabilities, with various flow cells for VWD, DAD, FLD, Bio MDS, or LC/MS detection for highest adaptability
Featured References
- Publications
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- Parallel experiments in electrochemical CO2 reduction enabled by standardized analytics.
Contributors: Alessandro Senocrate, Francesco Bernasconi, Peter Kraus, Nukorn Plainpan, Jens Trafkowski, Fabian Tolle, Thomas Weber, Ulrich Sauter, & Corsin Battaglia. 26 June 2024
- Expediting online liquid chromatography for real-time monitoring of product attributes to advance process analytical technology in downstream processing of biopharmaceuticals. Tobias Graf, Lukas Naumann, Lea Bonnington, Jakob Heckel, Bernhard Spensberger, Sascha Klein, Christoph Brey, Ronnie Nachtigall, Maximilian Mroz, Thomas Vagn Hogg, Christopher McHardy, Andres Martinez, Reinhard Braaz & Michael Leiss. 16 August 2024
- Parallel experiments in electrochemical CO2 reduction enabled by standardized analytics.
