Agilent Seahorse XF Substrate Oxidation Stress Test kits
Discover Which Substrates Impact Your Cells'
Fate, Function, and Fitness
Agilent Seahorse XF Substrate Oxidation Stress Test kits
across research areas
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Understanding the intersections between metabolism and cancer biology.
Vander Heiden and DeBerardinis, Cell (2017), 168: 657–669. -
A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds.
Kalyanaraman et al., Redox Biology (2018), 14: 316–27.
Metabolic programming is emerging as a critical mechanism for altering immune cell activation, lineage commitment, and function. XF Substrate Oxidation Stress Tests can be used with various types of immune cells to investigate substrate dependence or reliance on one or more substrates for correct immune cell differentiation and/or function.
Check out these peer-reviewed publications to gain better understanding of substrate influence and immune cell function:
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Induction of innate immune memory: The role of cellular metabolism.
Domínguez-Andrés et al., Current Opinion in Immunology (2019), 56: 10–16. -
Fatty acid metabolism in CD8(+) T cell memory: Challenging current concepts.
Raud et al., Immunological Reviews (2018), 283: 213–31.
Mitochondrial substrate oxidation is relevant for driving cell phenotype and function. The different metabolic requirements of the diverse cell types (normal or diseased) present a unique opportunity for the development of novel therapies in many disease areas.
Check out these peer-reviewed publications to learn about recent advances in the role of metabolism in drug discovery:
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Targeting metabolism to regulate immune responses in autoimmunity and cancer.
Patel et al., Nature Reviews Drug Discovery (2019), 18: 669–688. -
Targeting immuno-metabolism to improve anti-cancer therapies.
Beezhold and Byersdorfer, Cancer Letters (2018), 414: 127–35.
Glutamine oxidation is indispensable for survival of human pluripotent stem cells.
Tohyama et al., Cell Metabolism (2016), 23(4): 663–74.
- Identify mitochondrial substrate dependencies that drive particular cell function or uncover metabolic liabilities in cancer cells.
- Explore how substrate reliance can lead to cell fate decisions for immune cell differentiation and function.
- Reveal how demand for a specific mitochondrial substrate is affected if an intervention, such as a genetic manipulation or drug treatment, is applied to the cell.